Johnson, C.A., Burridge, J.H., Strike, P., Wood, D. E. and Swain, I. D., 2004. The effect of combined use of botulinum toxin type A and functional electric stimulation in the treatment of spastic drop foot after stroke: a preliminary investigation. Archives of Physical Medicine and Rehabilitation, 85 (6), pp. 902-909.
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Objective To investigate the effect of combined botulinum toxin type A (BTX) and functional electric stimulation (FES) treatment on spastic drop foot in stroke. Design Nonblinded randomized controlled trial. Setting Hospitals. Participants Consecutive sample of 21 ambulant adults within 1 year after stroke with a spastic drop foot, of whom 18 completed the study. Interventions The treatment group received BTX injections (Dysport) on 1 occasion into the medial and lateral heads of the gastrocnemius (200U each) and tibialis posterior (400U each) muscles and FES, used on a daily basis for 16 weeks to assist walking. Both groups continued with physiotherapy at the same rate. Main outcome measures Walking speed, Physiological Cost Index, Modified Ashworth Scale, Rivermead Motor Assessment, and Medical Outcomes Study 36-Item Short-Form Health Survey. Results Walking speed increased over 12 weeks in both control (P=.020) and treatment groups (nonstimulated, P=.004; stimulated, P=.042). The baseline corrected (analysis of covariance) increase in mean walking speed at 12 weeks, relative to controls, was .04m/s (95% confidence interval [CI], .003–.090) without stimulation, and .09m/s (95% CI, .031–.150) with stimulation. Conclusions Combined treatment effectively improved walking and function. A larger study is needed to quantify the treatment effect and to investigate its impact on quality of life.
|Uncontrolled Keywords:||Botulinum toxin type A, Electric stimulation, Muscle spasticity, Rehabilitation, Stroke|
|Subjects:||Technology > Medicine and Health > Medicine and Surgery|
|Group:||School of Design, Engineering & Computing > Smart Technology Research Centre|
|Deposited By:||Prof Ian D Swain|
|Deposited On:||31 Jan 2010 18:53|
|Last Modified:||07 Mar 2013 15:20|
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