Allen, S. C., Vassallo, M. and Khattab, A. D., 2009. The threshold for sensing airflow resistance during tidal breathing rises in old age: implications for elderly patients with obstructive airways diseases. Age and Ageing, 38 (5), p. 548.
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Official URL: http://dx.doi.org/10.1093/ageing/afp110
Objective: to determine whether the ability of elderly subjects to detect a rise in airflow resistance is attenuated in old age, and to measure the magnitude and variability of such a change. Methods: we studied 124 healthy adults aged 20–86 years. Progressive external airflow resistance loading was used to measure the inspiratory and expiratory load detection thresholds (LDTs) during tidal breathing at rest. Results: the mean inspiratory LDT rose from 4.00 (3.06 SD) kPa.s/L in the 20–39 age group to 6.51 (6.20) in the 40–64 age group (NS) and 29.10 (13.58) in the 65 + age group (P < 0.00001). The inspiratory LDT was significantly correlated with age, mainly due to the higher thresholds in people over the age of 65 (r = 0.7860, P < 0.00001), but did not correlate with age-corrected forced vital capacity or respiratory rate. Expiratory LDT values and correlations were very similar. Day-to-day variability in LDTs tended to be higher in older subjects. Conclusion: the threshold for detecting external resistive loads during tidal breathing rises in old age. This appears to be a consequence of ageing processes rather than pathology, and might be a manifestation of a fall in proprioceptive acuity in elderly people. This finding has clinical implications for the self-management of asthma in old age. There is a need to conduct a similar study in patients with airways disease.
|Additional Information:||Part of a larger project with at least 2 more papers expected.|
|Uncontrolled Keywords:||airflow resistance; ageing; sensing threshold; asthma, respiratory proprioception, elderly|
|Subjects:||Technology > Medicine and Health > Medicine and Surgery|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||Prof Stephen Allen|
|Deposited On:||28 Feb 2010 17:46|
|Last Modified:||07 Mar 2013 15:21|
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