Wolbers, T., Wiener, J.M., Mallot, H.A. and Büchel, C., 2007. Differential Recruitment of the Hippocampus, Medial Prefrontal Cortex, and the Human Motion Complex during Path Integration in Humans. Journal of Neuroscience, 27 (35), pp. 9408-9416.
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Path integration, the ability to sense self-motion for keeping track of changes in orientation and position, constitutes a fundamental mechanism of spatial navigation and a keystone for the development of cognitive maps. Whereas animal path integration is predominantly supported by the head-direction, grid, and place cell systems, the neural foundations are not well understood in humans. Here we used functional magnetic resonance imaging and a virtual rendition of a triangle completion paradigm to test whether human path integration recruits a cortical system similar to that of rodents and nonhuman primates. Participants traveled along two legs of a triangle before pointing toward the starting location. In accordance with animal models, stronger right hippocampal activation predicted more accurate updating of the starting location on a trial-by-trial basis. Moreover, between-subjects fluctuations in response consistency were negatively correlated with bilateral hippocampal and medial prefrontal activation, and bilateral recruitment of the human motion complex (hMT+) covaried with individual path integration capability. Given that these effects were absent in a perceptual control task, the present study provides the first evidence that visual path integration is related to the dynamic interplay of self-motion processing in hMT+, higher-level spatial processes in the hippocampus, and spatial working memory in medial prefrontal cortex.
|Uncontrolled Keywords:||path integration; navigation; virtual reality; spatial memory; hippocampus; functional MRI|
|Group:||School of Design, Engineering & Computing > Psychology Research Group|
|Deposited By:||Dr J.M. Wiener|
|Deposited On:||18 Apr 2010 20:49|
|Last Modified:||07 Mar 2013 15:25|
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