Bunten, H., Liang, W.-J., Pounder, D., Seneviratne, C. and Osselton, D. M., 2011. CYP2B6 and OPRM1 gene variations predict methadone-related deaths. Addiction Biology, 16 (1), pp. 142-144.
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The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.
|Uncontrolled Keywords:||* CYP2B6; * fatalities; * metabolism; * methadone; * OPRM1; * pharmacogenomics|
|Subjects:||Science > Biology and Botany|
|Group:||School of Applied Sciences > Forensic and Biological Sciences|
|Deposited By:||Professor David Osselton|
|Deposited On:||28 Jun 2011 09:01|
|Last Modified:||07 Mar 2013 15:46|
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