Sutherland, P.D., Wee, M.Y.K., Weston-Smith, P., Skinner, T. and Thomas, P., 2001. The use of thromboembolic deterrent stockings and a sequential compression device to prevent spinal hypotension during caesarean section. International Journal of Obstetric Anaesthesia, 10 (Part 2), pp. 97-102.
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Hypotension is a common side effect of spinal anaesthesia for caesarean section. We have performed a randomised, controlled study to determine the efficacy of a sequential compression device (SCD) (Kendall) in combination with thromboembolic deterrent (TED) stockings (Kendall) to reduce the incidence of hypotension in this setting. Within 20 min of spinal injection, there was no statistically significant difference in the incidence of hypotension (defined as less than 100 mmHg and less than 80% of baseline blood pressure) (TED/SCD group 65%, control 80%, P = 0.12). However, there was a trend for those receiving TED/SCD prophylaxis to require less ephedrine to maintain normotension than the control group (median TED/SCD 3 mg, control 6 mg, P = 0.08). The administration of ephedrine deviated from protocol on a total of 46 occasions (2.3% of recordings). To try to reduce the influence of this, we reinspected our data using time to first episode of hypotension with a Kaplan-Meier survival analysis. This showed that the instantaneous risk (hazard) of developing hypotension was 1.8 (95% CI: 1.1-2.9) times higher in controls than those receiving TED/SCD prophylaxis (P = 0.02). Despite demonstrating some benefit of TED/SCD prophylaxis to prevent hypotension, we do not consider that the magnitude of this benefit warrants their routine use.
|Uncontrolled Keywords:||Clinical Trial; Randomized Controlled trial; Caesarean Birth section|
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Social Work and Social Policy|
|Deposited By:||Mr Adam Field|
|Deposited On:||18 Oct 2007|
|Last Modified:||07 Mar 2013 14:44|
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