Sweeting, I., Serjeant, B.E., Thomas, P. and Serjeant, G.R., 1997. Microchromatographic quantitation of hemoglobin A levels in phenotypes of sickle cell-beta+ thalassemia. (Short communication). Journal of Chromatography B: Biomedical Sciences and Applications, 700 (1-2), pp. 269-274.
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The inheritance of the sickle cell gene in combination with a gene for β+ thalassemia results in a spectrum of sickle cell-β+ thalassemia syndromes with varying levels of hemoglobin A (HbA). Some sever sickle cell-β+ thalassemia syndromes have small amount of HbA, which may be difficult to quantitate in the presence of fetal homoglobin. A microcolumn chromatographic method, using 0.5 M Tris-acetic acids developers with varying pH values from 9.0 to 6.0, appears to adequately quantitate small amounts of HbA. This method is relatively simple and cheaper than high-performance liquid chromatography, a major consideration in developing countries.
|Uncontrolled Keywords:||Hemoglobin A|
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Social Work and Social Policy|
|Deposited By:||Mr Adam Field|
|Deposited On:||18 Oct 2007|
|Last Modified:||07 Mar 2013 14:44|
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