Watson, J.M., Lunt, M. J., Morris, S., Weiss, M.J., Hussey, D. and Kerr, D., 2000. Reversal of caffeine withdrawal by ingestion of a soft beverage. Pharmacology Biochemistry and Behavior, 66 (1), p. 1518.
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Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Following regular use, acute cessation of caffeine is associated with a characteristic withdrawal syndrome. Despite this, caffeine remains popular with its consumers. The aim of this study was to examine the physiologic and psychologic effects of small caffeine doses, administered in the form of a market-leading soft drink, on healthy women who were acutely withdrawn from caffeine. After 48-h abstinence and overnight fast, 11 healthy (22 to 40 years) female volunteers, all regular caffeine users (daily consumption 143 to 773mg) consumed using a double-blind, randomized, controlled cross-over design either 2 tins of regular or caffeine-free Diet Coke. On both visits a Mars bar was eaten to prevent hypoglycaemia. Thus, the caffeine load was 76 or 10 mg respectively. Following ingestion of regular Diet Coke, there was a 10% fall in middle cerebral artery velocity (95%CI [6%-14%], p < 0.005 versus caffeine free) and improvement in feelings of pleasure (p < 0.046) and energy (p < 0.037). Intellectual function (4-choice reaction time) was unaffected by caffeine status. On both visits, ingestion of Diet Coke induced a pressor response (maximum rise in systolic pressure +15 +/- 2 mm Hg with caffeine and +12 +/- 2 mm Hg with caffeine-free beverage, both p < 0.001 compared with baseline). In conclusion, in women acutely withdrawn from caffeine, ingestion of a popular soft beverage containing modest amounts of caffeine is associated with demonstrable physiologic and psychologic effects.
|Subjects:||Technology > Medicine and Health > Medicine and Surgery|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||Ms MJ Bowden|
|Deposited On:||15 Feb 2008 15:52|
|Last Modified:||07 Mar 2013 14:46|
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