Richardson, T., Thomas, P., Ryder, J. and Kerr, D., 2005. Influence of caffeine on frequency of hypoglycemia detected by continuous interstitial glucose monitoring system in patients with long-standing type 1 diabetes. Diabetes Care, 28, pp. 1316-1320.
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Official URL: http://care.diabetesjournals.org/cgi/content/abstr...
OBJECTIVE—The aim of this study was to investigate the effect of caffeine (in doses equivalent to normal daily ingestion) on rates and severity of hypoglycemia in patients with long-standing type 1 diabetes to determine the relationship between caffeine, autonomic function, and hypoglycemia. RESEARCH DESIGN AND METHODS—Using a double-blinded randomized study, we investigated the effect of caffeine versus placebo in 19 patients with long-standing type 1 diabetes using continuous glucose sensing technology and simultaneous assessment of autonomic function using Holter monitoring. RESULTS—Caffeine reduced the duration of nocturnal hypoglycemia with a mean duration of 49 minutes (range 0–235) versus 132 (0–468) minutes (P = 0.035). The reduction in duration of nighttime hypoglycemia was due to a decline in the number of episodes of moderate hypoglycemia at the expense of mild hypoglycemic episodes (P = 0.04). There was no overall correlation between reduced heart rate variability (a marker of autonomic dysfunction) and hypoglycemic events (rs = 0.12, P = 0.62). CONCLUSIONS—Our results suggest that caffeine is associated with a significant reduction in nocturnal hypoglycemia. The reduction in nocturnal hypoglycemia was not linked to the concomitant rise in parasympathetic activity associated with caffeine.
|Uncontrolled Keywords:||CGMS, continuous glucose monitoring system • HRV, heart rate variability • NREM, nonrapid eye movement|
|Subjects:||Technology > Medicine and Health > Medicine and Surgery|
|Group:||School of Health and Social Care > Centre for Social Work and Social Policy|
|Deposited By:||Ms MJ Bowden|
|Deposited On:||21 Feb 2008 13:20|
|Last Modified:||07 Mar 2013 14:46|
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