Simpson, S., Baldwin, R. C., Jackson, A., Burns, A. and Thomas, P., 2000. Is the Clinical Expression of Late-Life Depression Influenced by Brain Changes? MRI Subcortical Neuroanatomical Correlates of Depressive Symptoms. International Psychogeriatrics, 12 (4), pp. 425-434.
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Official URL: http://dx.doi.org/10.1017/S1041610200006542
Background: “Vascular depression” has recently been proposed. It is characterized by magnetic resonance imaging (MRI) T2-weighted subcortical lesions, a late onset of first episode of depression, and reduced heritability; a cerebrovascular etiology is suggested. The validity of “vascular depression” might be strengthened if an association was found between the subcortical lesions used to define it and particular depressive symptoms. Methods: A blinded cross-sectional examination of DSM-III-R depressive symptoms (American Psychiatric Association, 1987) and MRI T2-weighted subcortical lesions in 44 patients with late-life depression. Results: Many associations were found; however, because of multiple comparisons, their significance is viewed with caution. The most robust finding was that psychomotor retardation was independently related to total white-matter score. The odds of showing psychomotor retardation was increased 1.9 times for every point increase in severity of white-matter change. Conclusion: In late-life depression the clinical expression of the depression is influenced by the pattern of MRI T2-weighted subcorticallesions. This gives some validity to the concept of an MRI-defined “vascular” subtype of late-life depression and strengthens the argument for including neuroimaging in the classification of late-life depression. Peter Thomas
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Social Work and Social Policy|
|Deposited By:||INVALID USER|
|Deposited On:||03 Sep 2008 13:18|
|Last Modified:||07 Mar 2013 14:50|
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