Chacko, J., Pennell, D. J., Tanner, M. A., Hamblin, T. J.H., Wonke, B., Levy, T. M., Thomas, P. and Killick, S. B., 2007. Myocardial iron loading by magnetic resonance imaging T2* in good prognostic myelodysplastic syndrome patients on long-term blood transfusions. British Journal of Haematology, 138 (5), pp. 587-593.
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Official URL: http://www3.interscience.wiley.com/journal/1185177...
Magnetic resonance imaging (MRI) was used to quantify myocardial iron loading by T2* in 11 transfusion-dependent good prognostic myelodysplastic syndrome (MDS) patients. Myocardial T2*, left ventricular function and hepatic T2* were measured simultaneously. Patients had been on transfusion therapy for 13–123 months and had serum ferritin levels of 1109–6148 μg/l at the time of study. Five patients had not commenced iron chelation and had been transfused with a median of 63 red cell units and had a median serum ferritin level of 1490 μg/l. Six patients were on iron chelation and had been transfused with a median of 112 red cell units and had a median serum ferritin level of 4809 μg/l. Hepatic iron overload was mild in two, moderate in seven and severe in two patients. The median liver iron concentration was 5·9 mg/g dry weight in chelated patients and 9·5 mg/g in non-chelated patients (P = 0·17; not significant). Myocardial T2* indicated absent iron loading in 10/11 patients (91%; 95% confidence interval 62–98%) and borderline-normal in one patient. Left ventricular function was normal in all patients. No correlation was observed between increasing serum ferritin levels, hepatic iron overload and myocardial T2*. A long latent period relative to hepatic iron loading appears to predate the development of myocardial iron loading in transfusion-dependent MDS patients.
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|Deposited On:||03 Sep 2008 18:32|
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