Dyer, M. J.S. and Oscier, D. G., 2002. The configuration of the immunoglobin genes in B cell chronic lymphocytic leukemia. Leukemia, 16 (6), pp. 973-984.
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B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin V[sub H] gene segment mutation analysis has provided insights into the pathogenesis of these diseases and allowed the development of powerful prognostic markers. Immunoglobulin gene chromosomal translocations are rare in CLL and involve a distinct subset of genes including BCL3, BCL11A and CCND2. BCL2 translocations in CLL appear to arise via a different mechanism from comparable translocations seen in B cell nonHodgkin lymphoma.
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||INVALID USER|
|Deposited On:||19 Oct 2008 20:24|
|Last Modified:||07 Mar 2013 14:51|
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