Sahota, S. S., Forconi, F., Ottensmeier, C. H., Provan, D., Oscier, D. G., Hamblin, T. J.H. and Stevenson, F. K., 2002. Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood, 100 (4), pp. 1505-1507.
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Official URL: http://bloodjournal.hematologylibrary.org/cgi/cont...
There exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior. Knowledge of the VH gene status can reveal their origin and clonal history. For Waldenstrom macroglobulinemia (WM), a distinct subtype of lymphoplasmacytic lymphoma, early data on limited sequences showed evidence for somatic mutation. A recent report of one case demonstrated intraclonal mutational activity occurring after transformation, a characteristic of germinal center lymphomas. To extend the investigation, we have analyzed 7 cases of WM. VH genes were somatically mutated with no evidence of intraclonal variation in all cases. In contrast to IgM-secreting multiple myeloma, there was no evidence for isotype switch transcripts in any of the cases. These data support the concept that typical WM is derived from a B cell that has undergone somatic mutation prior to transformation, at a point where isotype switch events have not been initiated.
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||INVALID USER|
|Deposited On:||19 Oct 2008 20:27|
|Last Modified:||07 Mar 2013 14:51|
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