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Scherer, S.W., Cheung, J., MacDonald, J. R., Osborne, L. R., Nakabayashi, K., Herbrick, J.-A., Carson, A. R., Parker-Katiraee, L., Skaug, J., Khaja, R., Zhang, J., Hudek, A. K., Li, M., Haddad, M., Duggan, G. E., Fernandez, B. A., Kanematsu, E., Gentles, S., Christopoulos, C. C., Choufani, S., Kwasnicka, D., Zheng, X. H., Lai, Z., Nusskern, D., Zhang, Q., Gu, Z., Lu, F., Zeesman, S., Nowaczyk, M. J., Teshima, I., Chitayat, D., Shuman, C., Weksberg, R., Zackai, E. H., Grebe, T. A., Cox, S. R., Kirkpatrick, S. J., Rahman, N., Friedman, J. M., Heng, H. H. Q., Pelicci, P. G., Lo-Coco, F., Belloni, E., Shaffer, L. G., Pober, B., Morton, C. C., Gusella, J. F., Bruns, G. A. P., Korf, B. R., Quade, B. J., Ligon, A. H., Ferguson, H., Higgins, A. W., Leach, N. T., Herrick, S. R., Lemyre, E., Farra, C. G., Kim, H.-G., Summers, A. M., Gripp, K. W., Roberts, W., Szatmari, P., Winsor, E. J.T., Grzeschik, K.-H., Teebi, A., Minassian, B. A., Kere, J., Armengol, L., Pujana, M. A., Estivill, X., Wilson, M. D., Koop, B. F., Tosi, S., Moore, G. E., Boright, A. P., Zlotorynski, E., Kerem, B., Kroisel, P. M., Petek, E., Oscier, D. G., Mould, S. J., Dohner, H., Dohner, K., Rommens, J. M., Vincent, J. B., Venter, J. C., Li, P. W., Mural, R. J., Adams, M. D. and Tsui, L.-C., 2003. Human Chromosome 7: DNA Sequence and Biology. Science, 300 (5620), pp. 767-772.
Full text not available from this repository.
Official URL: http://www.sciencemag.org/cgi/content/abstract/300...
Abstract
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
| Item Type: | Article |
|---|---|
| ISSN: | 0036-8075 |
| Subjects: | Technology > Medicine and Health |
| Group: | School of Health and Social Care > Centre for Postgraduate Medical Research and Education |
| ID Code: | 6248 |
| Deposited By: | INVALID USER |
| Deposited On: | 19 Oct 2008 20:43 |
| Last Modified: | 07 Mar 2013 14:51 |
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