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Strathdee, G., Sim, A., Parker, A. E., Oscier, D. G. and Brown, R., 2006. Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. Leukemia, 20, pp. 1326-1329.
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Official URL: http://www.nature.com/leu/journal/v20/n7/abs/24042...
Abstract
The article investigates the potential of DNA methylation to alter Hox gene expression in leukemia. Hox genes are involved in leukemia-associated translocations and aberrant expression of Hox genes is a common event in leukemogenesis. Overexpression of multiple Hox genes has been identified in both lymphoid and myeloid malignancies.
| Item Type: | Article |
|---|---|
| ISSN: | 0887-6924 |
| Subjects: | Technology > Medicine and Health |
| Group: | School of Health and Social Care > Centre for Postgraduate Medical Research and Education |
| ID Code: | 6270 |
| Deposited By: | INVALID USER |
| Deposited On: | 02 Nov 2008 16:03 |
| Last Modified: | 07 Mar 2013 14:51 |
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