Strathdee, G., Sim, A., Parker, A. E., Oscier, D. G. and Brown, R., 2006. Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. Leukemia, 20, pp. 1326-1329.
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Official URL: http://www.nature.com/leu/journal/v20/n7/abs/24042...
The article investigates the potential of DNA methylation to alter Hox gene expression in leukemia. Hox genes are involved in leukemia-associated translocations and aberrant expression of Hox genes is a common event in leukemogenesis. Overexpression of multiple Hox genes has been identified in both lymphoid and myeloid malignancies.
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||INVALID USER|
|Deposited On:||02 Nov 2008 16:03|
|Last Modified:||07 Mar 2013 14:51|
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