Amato, D., Oscier, D. G., Davis, Z. A., Mould, S. J., Zheng, J., Kolomietz, E. and Wang, C., 2007. Cytogenetic Aberrations and Immunoglobulin VH Gene Mutations in Clinically Benign CD5- Monoclonal B-Cell Lymphocytosis. American Journal of Clinical Pathology, 128 (2), pp. 333-338.
Full text not available from this repository.
Official URL: http://ajcp.metapress.com/app/home/contribution.as...
The finding of monoclonal B-cell lymphocytosis (MBL) raises questions on the nature of clonal cell expansion and its risk of progression. We identified and characterized 7 cases of clinically benign clonal B-cell lymphocytosis. The clonal lymphocytes were clearly of CD5– and non–chronic lymphocytic leukemia (CLL) phenotype. All cases had mild to moderate absolute lymphocytosis. The clonal population accounted for 95% to 99% of B cells. For a follow-up period of 4 to 16 years, clonal lymphocytosis was persistent but virtually not progressing. Patients' conditions remained clinically stable and asymptomatic. The clonal populations had somatic hypermutations of the VH gene in 6 cases, indicating a germinal center or post–germinal center B-lymphocyte origin. Clonal cytogenetic aberrations were found in 5 of 6 cases, with 2 clones bearing isochromosome 17q that resulted in loss of p53 and 2 other clones with 7q abnormalities. By the presence of absolute lymphocytosis, this series differs from MBL cases identified by sensitive flow cytometry in normal populations. The phenotypic profiles are distinct from that of benign CLL. We suggest these CD5– B-cell lymphocytosis cases may represent an intermediate condition between covert clonal expansions and overt malignancy.
|Subjects:||Technology > Medicine and Health|
|Group:||School of Health and Social Care > Centre for Postgraduate Medical Research and Education|
|Deposited By:||INVALID USER|
|Deposited On:||23 Oct 2008 13:44|
|Last Modified:||07 Mar 2013 14:51|
|Repository Staff Only -|
|BU Staff Only -|
|Help Guide -||Editing Your Items in BURO|