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Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal.

Aryal, N., Weatherall, M., Bhatta, Y.K.D. and Mann, S., 2017. Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal. International Journal of Environmental Research and Public Health, 14 (9), 1041.

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Lipid & diabetes_high altitude.pdf - Published Version
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DOI: 10.3390/ijerph14091041


This study aimed to describe lipid profiles and the distribution of glycated hemoglobin (HbA1c) in a sample of a high altitude population of Nepal and to explore associations between these metabolic risk variables and altitude. A cross-sectional survey of cardiovascular disease and associated risk factors was conducted among 521 people living at four different altitude levels, all above 2800 m, in the Mustang and Humla districts of Nepal. Urban participants (residents at 2800 m and 3620 m) had higher total cholesterol (TC) and triglyceride (TG) than rural participants. A high ratio of TC to high-density lipoprotein-cholesterol (HDL) (TC/HDL ≥ 5.0) was found in 23.7% (95% CI 19.6, 28.2) and high TG (≥1.7 mmol/L) in 43.3% (95% CI 38.4, 48.3) of participants overall. Mean HbA1c levels were similar at all altitude levels although urban participants had a higher prevalence of diabetes. Overall, 6.9% (95% CI 4.7, 9.8) of participants had diabetes or were on hypoglycaemic treatment. There was no clear association between lipid profiles or HbA1c and altitude in a multivariate analysis adjusted for possible confounding variables. Residential settings and associated lifestyle practices are more strongly associated with lipid profiles and HbA1c than altitude amongst high altitude residents in Nepal.

Item Type:Article
Uncontrolled Keywords:Nepal; diabetes; glycated hemoglobin; high altitude; high-density lipoprotein-cholesterol; lipid profile; low-density lipoprotein-cholesterol ; total cholesterol ; triglyceride ; Adult ; Aged ; Altitude ; Cross-Sectional Studies ; Diabetes Mellitus ; Female ; Glycated Hemoglobin A ; Humans ; Hyperlipidemias ; Lipids ; Male ; Middle Aged ; Multivariate Analysis ; Nepal ; Prevalence ; Risk Factors ; Triglycerides
Group:Faculty of Health & Social Sciences
ID Code:31341
Deposited By: Symplectic RT2
Deposited On:09 Oct 2018 14:34
Last Modified:14 Mar 2022 14:13


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