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Greater male than female variability in regional brain structure across the lifespan.

Wierenga, L.M., Doucet, G.E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T.N., Albajes-Eizagirr, A., Alnæs, D., Alpert, K.I., Andreassen, O.A., Anticevic, A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D.I., Borgwardt, S., Bourque, J., den Braber, A., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R.M., Buitelaar, J.K., Busatt, G.F., Calhoun, V.D., Canales-Rodríguez, E.J., Cannon, D.M., Caseras, X., Castellanos, F.X., Chaim-Avancin, T.M., Ching, C.R.K., Clark, V.P., Conrod, P.J., Conzelmann, A., Crivello, F., Davey, C.G., Dickie, E.W., Ehrlich, S., van't Ent, D., Fisher, S.E., Fouche, J.P., Franke, B., Fuentes-Claramonte, P., de Geus, E.J.C, Di Giorgio, A., Glahn, D.C., Gotlib, I.H., Grabe, H.J., Gruber, O., Gruner, P., Gur, R.E., Gur, R.C., Gurholt, T.P., de Haan, L., Haatveit, B., Harrison, B.J., Hartman, C.A., Hatton, S.N., Heslenfeld, D.J., van den Heuvel, O.A., Hickie, I.B., Hoekstra, P.J., Hohmann, S., Holmes, A.J., Hoogman, M., Hosten, N., Howells, F.M., Hulshoff Pol, H.E., Huyser, C., Jahanshad, N., James, A.C., Jiang, J., Jönsson, E.G., Joska, J.A., Kalnin, A.J., Consortium, K. S. P. (K.), Klein, M., Koenders, L., Kolskår, K.K., Krämer, B., Kuntsi, J., Lagopoulos, J., Lazaro, L., Lebedeva, I.S., Lee, P.H., Lochner, C., Machielsen, M.W.J., Maingault, S., Martin, N.G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, B.C., McDonald, C., McIntosh, A.M., McMahon, K.L., McPhilemy, G., van der Meer, D., Menchón, J.M., Naaijen, J., Nyberg, L., Oosterlaan, J., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M.J., Radua, J., Reif, A., Richards, G., Roffman, J.L., Rosa, P.G.P., Sacchet, M.D., Sachdev, P.S., Salvador, R., Sarró, S., Satterthwaite, T.D., Saykin, A.J., Serpa, M.H., Sim, K., Simmons, A., Smoller, J.W., Sommer, I.E., Soriano-Mas, C., Stein, D.J., Strike, L.T., Szeszko, P.R., Temmingh, H.S., Thomopoulos, S., Tomyshev, A.S., Trollor, J.N., Uhlmann, A., Veer, I.M., Veltman, D.J., Voineskos, A., Völzke, H., Walter, H., Wang, L., Wang, Y., Weber, B., Wen, W., West, J.D., Westlye, L.T., Whalley, H.C., Williams, S.C.R., Wittfeld, K., Wolf, D.H., Wright, M.J., Yoncheva, Y.N., Zanetti, M.V., Ziegler, G.C., de Zubicaray, G.I., Thompson, P.M., Crone, E.A., Frangou, S. and Tamnes, C.K., 2022. Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping, 43 (1), 470-499.

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Human Brain Mapping - 2020 - Wierenga - Greater male than female variability in regional brain structure across the.pdf - Published Version
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DOI: 10.1002/hbm.25204


For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.

Item Type:Article
Additional Information:Funding Information: BIG ‐ Nijmegen 1.5T Deutsche Forschungsgemeinschaft. Grant Numbers: KFO 125, TRR 58/A1, TRR 58/A5, SFB‐TRR 58/B01, SFB‐TRR 58/B06 Deutsche Forschungsgesellschaft collaborative research center. Grant Number: 636 EU H2020. Grant Number: #667302 European Community's Horizon 2020 Programme. Grant Numbers: 643051, 667302 European Community's Seventh Framework Programme. Grant Numbers: 602805, 603016, 602450, 278948 European Research Council. Grant Numbers: ERC‐2010‐StG‐263234, ERC‐230374 German Research Foundation. Grant Number: KFO 125 KA Wallenberg Foundation KNAW Academy Professor Award. Grant Number: PAH/6635 Miguel Servet Research Contract. Grant Number: CPII16/0020 Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Grant Numbers: 51.02.061 to H.H., NWO 51.02.062 to D.B., NWO‐ NIH Netherlands Brain Foundation grant. Grant Number: 2010(1)‐50 NIA. Grant Number: T32AG058507 NIH/NIMH. Grant Numbers: 5T32MH073526, U54EB020403, U54 EB020403, R56 AG058 NIHR Biomedical Research Centre for Mental Health. Grant Number: NIHR/MRC (14/23/17) NIHR senior investigator award. Grant Number: NF‐SI‐0616‐10040 NWO Brain & Cognition Excellence Program. Grant Number: 433‐09‐ 229 Research Council of Norway. Grant Numbers: #223273, #288083, #230345 South London and Maudsley Trust. Grant Number: 064846 South‐Eastern Norway Regional Health Authority. Grant Numbers: #2017112, #2019069 the Generalitat de Catalunya. Grant Number: 2017SGR01343 the German Research Foundation. Grant Numbers: WA 1539/4‐1, SCHN 1205/3‐1 The Marató TV3 Foundation. Grant Numbers: #091710, #091710 UK Medical Research Council Grant. Grant Number: G03001896 to J Kuntsi Vici Innovation Program. Grant Numbers: 016‐130‐669, 91619115 National Institute of Aging. Grant Number: R03AG064001 National Institute of General Medical Sciences. Grant Number: P20GM130447
Group:Faculty of Health & Social Sciences
ID Code:34689
Deposited By: Symplectic RT2
Deposited On:13 Oct 2020 13:45
Last Modified:14 Mar 2022 14:24


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