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The relation of structural integrity and task-related functional connectivity in the aging brain.

Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D., 2015. The relation of structural integrity and task-related functional connectivity in the aging brain. Neurobiology of Aging, 36 (10), 2830 -2837.

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DOI: 10.1016/j.neurobiolaging.2015.07.006


The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

Item Type:Article
Uncontrolled Keywords:Age-related compensation; Functional connectivity; Gray matter; Structural integrity; White matter; Adult; Aged; Aging; Brain; Cognition; Diffusion Magnetic Resonance Imaging; Female; Humans; Male; Memory; Middle Aged; Nerve Net; Neuroimaging; Organ Size; Young Adult
Group:Faculty of Science & Technology
ID Code:35327
Deposited By: Symplectic RT2
Deposited On:25 Mar 2021 16:12
Last Modified:14 Mar 2022 14:26


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