Fairbairn, P., Dyall, S. C. and Tsofliou, F., 2022. The Effects of Multi-Nutrient Formulas containing a Combination of Omega-3 Polyunsaturated Fatty Acids and B vitamins on Cognition in the older adult: A Systematic Review and Meta-analysis. The British Journal of Nutrition, 129 (3), 428-441.
Full text available as:
|
PDF (OPEN ACCESS ARTICLE)
the-effects-of-multi-nutrient-formulas-containing-a-combination-of-n-3-pufa-and-b-vitamins-on-cognition-in-the-older-adult-a-systematic-review-and-meta-analysis.pdf - Published Version Available under License Creative Commons Attribution. 1MB | |
PDF (OPEN ACCESS ARTICLE)
the-effects-of-multi-nutrient-formulas-containing-a-combination-of-n-3-pufa-and-b-vitamins-on-cognition-in-the-older-adult-a-systematic-review-and-meta-analysis.pdf - Published Version Restricted to Repository staff only Available under License Creative Commons Attribution. 1MB | ||
PDF
the-effects-of-multi-nutrient-formulas-containing-a-combination-of-omega-3-polyunsaturated-fatty-acids-and-b-vitamins-on-cognition-in-the-older-adult-a-systematic-review-and-meta-analysis.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Attribution. 874kB | ||
Copyright to original material in this document is with the original owner(s). Access to this content through BURO is granted on condition that you use it only for research, scholarly or other non-commercial purposes. If you wish to use it for any other purposes, you must contact BU via BURO@bournemouth.ac.uk. Any third party copyright material in this document remains the property of its respective owner(s). BU grants no licence for further use of that third party material. |
DOI: 10.1017/S0007114522001283
Abstract
There is now evidence to suggest that there may be an interaction between B vitamins and omega-3 polyunsaturated fatty acids (PUFAs), with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of omega-3 PUFAs and B vitamins can prevent cognitive decline in older adults. Randomised control trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of omega-3 PUFAs and B vitamins alone, or in combination with other nutrients. Trials that provided omega-3 PUFAs alone and also measured B vitamin status or provided B vitamin supplementation alone and measured omega-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus, and MEDLINE. A total of 14 papers were included in the analysis (n=4913; age: 60-70 y; follow up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both omega-3 PUFAs and B vitamins alongside other nutrients, versus placebo on global cognition assessed using composite scores from a neuropsychological test battery (G=0.23, P=0.002), global cognition using single measures of cognition (G=0.28, P=0.004) and episodic memory (G=0.32, P=0.001). The results indicate that providing a combination of omega-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults versus a placebo, the potential for an interaction between these key nutrients should be considered in future experimental work.
Item Type: | Article |
---|---|
ISSN: | 0007-1145 |
Uncontrolled Keywords: | Omega-3 Polyunsaturated Fatty Acids; B Vitamins; Cognition; Memory; Older Adults |
Group: | Faculty of Science & Technology |
ID Code: | 36903 |
Deposited By: | Symplectic RT2 |
Deposited On: | 03 May 2022 13:51 |
Last Modified: | 04 Apr 2023 12:13 |
Downloads
Downloads per month over past year
Repository Staff Only - |