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DOI: 10.1038/s41598-022-15661-1
Abstract
Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. Here we analysed SARS-CoV-2 whole genome sequences in combination with epidemiological data to investigate a large cluster of student cases associated with University of Glasgow accommodation in autumn 2020, Scotland. We identified 519 student cases of SARS-CoV-2 infection associated with this large cluster through contact tracing data, with 30% sequencing coverage for further analysis. We estimated at least 11 independent introductions of SARS-CoV-2 into the student population, with four comprising the majority of detected cases and consistent with separate outbreaks. These four outbreaks were curtailed within a week following implementation of control measures. The impact of student infections on the local community was short-term despite an underlying increase in community infections. Our study highlights the need for context-specific information in the formation of public health policy for higher educational settings.
Item Type: | Article |
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ISSN: | 2045-2322 |
Uncontrolled Keywords: | COVID-19; Disease Outbreaks; Genomics; Health Planning; Humans; SARS-CoV-2; United States; Universities |
Group: | Faculty of Science & Technology |
ID Code: | 37306 |
Deposited By: | Symplectic RT2 |
Deposited On: | 01 Aug 2022 15:36 |
Last Modified: | 01 Aug 2022 15:36 |
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