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The underlying mechanisms by which PTSD symptoms are associated with cardiovascular heath in male UK military personnel: The ADVANCE cohort study.

Dyball, D., Bennett, A. N., Schofield, S., Cullinan, P., Boos, C. J., Bull, A. M. J., Stevelink, S. A., Fear, N. T. and ADVANCE Study, , 2023. The underlying mechanisms by which PTSD symptoms are associated with cardiovascular heath in male UK military personnel: The ADVANCE cohort study. Journal of Psychiatric Research, 159, 87-96.

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DOI: 10.1016/j.jpsychires.2023.01.010


Post-Traumatic Stress Disorder (PTSD) has been identified as an independent risk factor for cardiovascular disease, but the mechanisms of this relationship are not well understood. This study investigates the associations between PTSD symptom clusters (hyperarousal, intrusive thoughts, avoidance behaviours and emotional numbing) and mechanisms of cardiovascular disease including cardiometabolic effects, inflammation, and haemodynamic functioning. In the ADVANCE study cohort of UK male military personnel, 1111 participants were assessed for PTSD via questionnaire and cardiovascular risk via venous blood sampling, pulse wave analysis and dual energy x-ray absorptiometry between 2015 and 2020. Variable selection procedures were conducted to assess which of the symptom clusters if any were associated with cardiovascular risk outcomes. Associations were confirmed via robust regression modelling. Avoidance behaviours were associated with greater systolic Blood Pressure (BP) (Adjusted Coefficient (AC) 0.640 (95% Confidence Interval (CI) 0.065, 1.149). Emotional numbing was associated with greater estimated glucose disposal rate (AC -0.021 (95%CI -0.036, -0.005). Hyperarousal was associated with greater levels of (log)triglycerides (exponentiated-AC 1.009 (95%CI 1.002, 1.017). Intrusive thoughts were associated with greater visceral adipose tissue (AC 0.574 (95%CI 0.020, 1.250). Nonlinear relationships were observed between emotional numbing with heart rate and intrusive thoughts with systolic BP. Limited evidence is present for symptom associations with lipoproteins and pulse wave velocity. No associations were observed between PTSD symptom clusters and high sensitivity c-reactive protein, diastolic BP, total cholesterol, or haemoglobin fasting glucose. In conclusion, symptom clusters of PTSD were associated with increased cardiovascular risk via cardiometabolic and haemodynamic functioning mechanisms, but not inflammation.

Item Type:Article
Uncontrolled Keywords:ADVANCE cohort; Heart disease risk factors; Hemodynamics; Inflammation; Military personnel; Post-traumatic; Stress disorders
Group:Faculty of Health & Social Sciences
ID Code:38116
Deposited By: Symplectic RT2
Deposited On:01 Feb 2023 16:34
Last Modified:01 Feb 2023 16:34


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