Fairbairn, P., Dyall, S. C. and Tsofliou, F., 2022. The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis. British Journal of Nutrition, 129 (3), 428-441.
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DOI: 10.1017/S0007114522001283
Abstract
There is now evidence to suggest that there may be an interaction between B vitamins and n-3 PUFA, with suggestions that increasing intake of both nutrients simultaneously may benefit cognition in older adults. The aim of this systematic review was to investigate whether supplementation with a combination of n-3 PUFA and B vitamins can prevent cognitive decline in older adults. Randomised controlled trials conducted in older adults that measured cognitive function were retrieved. The included trials provided a combination of n-3 PUFA and B vitamins alone, or in combination with other nutrients. Trials that provided n-3 PUFA alone and also measured B vitamin status or provided B vitamin supplementation alone and measured n-3 PUFA status were also included. The databases searched were The Cochrane Library, EMBASE, CINAHL, Scopus and MEDLINE. A total of 14 papers were included in the analysis (n 4913; age: 60–70 years; follow-up 24 weeks to 4 years). The meta-analysis results found a significant benefit of nutrient formulas, which included both n-3 PUFA and B vitamins alongside other nutrients, v. placebo on global cognition assessed using composite scores from a neuropsychological test battery (G = 0·23, P = 0·002), global cognition using single measures of cognition (G = 0·28, P = 0·004) and episodic memory (G = 0·32, P = 0·001). The results indicate that providing a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula benefits cognition in older adults v. a placebo, and the potential for an interaction between these key nutrients should be considered in future experimental work.
Item Type: | Article |
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ISSN: | 0007-1145 |
Uncontrolled Keywords: | n-3 PUFA; B vitamins; Cognition; Memory; Older adults; Folic Acid and Carotid Intimamedia Thickness; mild cognitive impairment; randomised controlled trial; Vitamins in Cognitive Impairment |
Group: | Faculty of Health & Social Sciences |
ID Code: | 38129 |
Deposited By: | Symplectic RT2 |
Deposited On: | 02 Feb 2023 15:17 |
Last Modified: | 02 Feb 2023 15:17 |
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