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Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease.

Kvavilashvili, L., Niedźwieńska, A., Gilbert, S. J. and Markostamou, I., 2020. Deficits in Spontaneous Cognition as an Early Marker of Alzheimer's Disease. Trends in Cognitive Sciences, 24 (4), 285-301.

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2020 Kvavilashvili-Markostamou_TiCS_Spontaneous_Cognition_Accepted.pdf - Accepted Version
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DOI: 10.1016/j.tics.2020.01.005


In the absence of a pharmacological cure, finding the most sensitive early cognitive markers of Alzheimer's disease (AD) is becoming increasingly important. In this article we review evidence showing that brain mechanisms of spontaneous, but stimulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years before the clinical symptoms of AD. This leads to the formulation of a novel hypothesis which predicts that spontaneous, but stimulus-dependent, conscious retrieval processes, that are generally intact in healthy aging, will be particularly compromised in people at the earliest stages of AD. Initial evidence for this hypothesis is presented across diverse experimental paradigms (e.g., prospective memory, mind-wandering), and new avenues for research in this area are outlined.

Item Type:Article
Uncontrolled Keywords:default mode network; involuntary memory; mild cognitive impairment; mind-wandering; posterior cingulate cortex; prospective memory; spontaneous retrieval; Alzheimer Disease; Brain; Cognition; Humans; Magnetic Resonance Imaging; Memory, Episodic; Nerve Net
Group:Faculty of Science & Technology
ID Code:39406
Deposited By: Symplectic RT2
Deposited On:18 Jan 2024 14:57
Last Modified:18 Jan 2024 14:57


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