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The effect of high-frequency rTMS over left DLPFC and fluid abilities on goal neglect.

Arabacı, G., Cakir, B. S. and Parris, B. A., 2024. The effect of high-frequency rTMS over left DLPFC and fluid abilities on goal neglect. Brain Structure and Function. (In Press)

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s00429-024-02770-y.pdf - Published Version
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DOI: 10.1007/s00429-024-02770-y


Goal neglect refers to when an aspect of task instructions is not utilised due to increased competition between goal representations, an attentional limit theoretically linked to working memory. In an attempt to alleviate goal neglect and to investigate the association between dorsolateral prefrontal cortex (DLPFC)-supported working memory and goal neglect, we used high-frequency repetitive transcranial magnetic stimulation to the left DLPFC whilst participants completed the letter-monitoring task, a measure of goal neglect, and an N3-back task, a working memory task known to be affected by rTMS of the left DLPFC, following 20 min of active and sham stimulation (run on separate days). We found increased accuracy on the N3-back task in addition to decreased goal neglect in the active compared to sham condition when controlling for age and fluid abilities (as assessed by matrix reasoning performance). Furthermore, analysis showed that active stimulation improvements on both the N3-back and letter-monitoring tasks were greater for those with higher fluid abilities. These findings provide support for the link between the DLPFC-support working memory and goal neglect. Increased performance on the N3-back task also supports the literature reporting a link between left DLPFC and verbal working memory. Results are evaluated in the context of potential use to alleviate symptoms of disorders related to goal neglect.

Item Type:Article
Uncontrolled Keywords:DLPFC; Goal neglect; High frequency; Working memory; rTMS
Group:Faculty of Science & Technology
ID Code:39743
Deposited By: Symplectic RT2
Deposited On:25 Apr 2024 14:17
Last Modified:25 Apr 2024 14:17


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