Appleton, K., Grippo, A.J., Beltz, T.G. and Johnson, A.K, 2015. Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 95, 11-18.
Full text available as:
|
PDF (OPEN ACCESS ARTICLE)
Appleton.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 1MB | |
Copyright to original material in this document is with the original owner(s). Access to this content through BURO is granted on condition that you use it only for research, scholarly or other non-commercial purposes. If you wish to use it for any other purposes, you must contact BU via BURO@bournemouth.ac.uk. Any third party copyright material in this document remains the property of its respective owner(s). BU grants no licence for further use of that third party material. |
DOI: 10.1016/j.plefa.2014.11.010
Abstract
n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
Item Type: | Article |
---|---|
ISSN: | 0952-3278 |
Uncontrolled Keywords: | Behavioural tests ; Deoxycorticosterone acetate (DOCA) ; Plasma ; Stress ; n3 Polyunsaturated fatty acids (n-3PUFAs) |
Group: | Faculty of Science & Technology |
ID Code: | 21648 |
Deposited By: | Symplectic RT2 |
Deposited On: | 19 Jan 2015 12:37 |
Last Modified: | 14 Mar 2022 13:50 |
Downloads
Downloads per month over past year
Repository Staff Only - |