Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats.

Appleton, K., Grippo, A.J., Beltz, T.G. and Johnson, A.K, 2015. Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 95, pp. 11-18.

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DOI: 10.1016/j.plefa.2014.11.010

Abstract

n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.

Item Type:Article
ISSN:0952-3278
Uncontrolled Keywords:Behavioural tests ; Deoxycorticosterone acetate (DOCA) ; Plasma ; Stress ; n3 Polyunsaturated fatty acids (n-3PUFAs)
Subjects:UNSPECIFIED
Group:Faculty of Science and Technology
ID Code:21648
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:19 Jan 2015 12:37
Last Modified:11 Nov 2015 12:59

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