Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids.

Dyall, S., 2010. Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids. International Journal of Alzheimer's Disease , pp. 1-10.

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DOI: 10.4061/2010/274128

Abstract

Alzheimer’s disease is the most common form of dementia in the elderly and is a progressive neurodegenerative disorder characterised by a decline in cognitive function and also profound alterations in mood and behaviour. The pathology of the disease is characterised by the presence of extracellular amyloid peptide deposits and intracellular neurofibrillary tangles in the brain. Although many hypotheses have been put forward for the aetiology of the disease, increased inflammation and oxidative stress appear key to be features contributing to the pathology. The omega-3 polyunsaturated fats, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have well-characterised e ff ects on inflammation and may have neuroprotective e ff ects in a number of neurodegenerative conditions including Alzheimer’s disease. The aims of this paper are to review the neuroprotective e ff ects of EPA and DHA in Alzheimer’s disease, with special emphasis on their role in modulating oxidative stress and inflammation and also examine their potential as therapeutic agents

Item Type:Article
ISSN:2090-8024
Subjects:UNSPECIFIED
Group:School of Health and Social Care
ID Code:21699
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:19 Feb 2015 09:25
Last Modified:19 Feb 2015 09:25

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