Varrella, S., Ruocco, N., Costantini, M., Romano, G., Ianora, A., Costantini, S. and Bentley, M.G., 2016. Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins. PLoS One, 11 (2), 1 - 21 .
Full text available as:
|
PDF
Varrella_et_al_2016.pdf - Published Version Available under License Creative Commons Attribution. 3MB | |
Copyright to original material in this document is with the original owner(s). Access to this content through BURO is granted on condition that you use it only for research, scholarly or other non-commercial purposes. If you wish to use it for any other purposes, you must contact BU via BURO@bournemouth.ac.uk. Any third party copyright material in this document remains the property of its respective owner(s). BU grants no licence for further use of that third party material. |
Official URL: http://journals.plos.org/plosone/
DOI: 10.1371/journal.pone.0149734
Abstract
Marine organisms possess a series of cellular strategies to counteract the negative effects of toxic compounds, including the massive reorganization of gene expression networks. Here we report the modulated dose-dependent response of activated genes by diatom polyunsaturated aldehydes (PUAs) in the sea urchin Paracentrotus lividus. PUAs are secondary metabolites deriving from the oxidation of fatty acids, inducing deleterious effects on the reproduction and development of planktonic and benthic organisms that feed on these unicellular algae and with anti-cancer activity. Our previous results showed that PUAs target several genes, implicated in different functional processes in this sea urchin. Using interactomic Ingenuity Pathway Analysis we now show that the genes targeted by PUAs are correlated with four HUB genes, NF-κB, p53, δ-2-catenin and HIF1A, which have not been previously reported for P. lividus. We propose a working model describing hypothetical pathways potentially involved in toxic aldehyde stress response in sea urchins. This represents the first report on gene networks affected by PUAs, opening new perspectives in understanding the cellular mechanisms underlying the response of benthic organisms to diatom exposure.
Item Type: | Article |
---|---|
ISSN: | 1932-6203 |
Uncontrolled Keywords: | Aldehydes; GENE regulatory networks; DIATOMS; SEA urchins; FATTY acid oxidation; Polyenes |
Group: | Faculty of Science & Technology |
ID Code: | 23176 |
Deposited By: | Symplectic RT2 |
Deposited On: | 01 Mar 2016 13:46 |
Last Modified: | 14 Mar 2022 13:54 |
Downloads
Downloads per month over past year
Repository Staff Only - |