As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Blice-Baum, A.C., Guida, M.C., Hartley, P. S., Adams, P.D., Bodmer, R. and Cammarato, A., 2018. As time flies by: Investigating cardiac aging in the short-lived Drosophila model. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (In Press)

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Official URL: https://www.sciencedirect.com/science/article/pii/...

DOI: 10.1016/j.bbadis.2018.11.010

Abstract

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.

Item Type:Article
ISSN:0925-4439
Uncontrolled Keywords:Cardiac aging ; Epigenetics ; Fruit fly ; Obesity ; Proteostasis
Group:Faculty of Science & Technology
ID Code:31626
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:10 Jan 2019 14:04
Last Modified:10 Jan 2019 14:04

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