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Prenatal Intake of Vitamins and Allergic Outcomes in the Offspring: A Systematic Review and Meta-Analysis.

Vahdaninia, M., Mackenzie, H., Helps, S. and Dean, T., 2017. Prenatal Intake of Vitamins and Allergic Outcomes in the Offspring: A Systematic Review and Meta-Analysis. The Journal of Allergy and Clinical Immunology: In Practice, 5 (3), 771-778.e5.

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Vahdaninia et al 2016 JACI In Practice.pdf - Accepted Version
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DOI: 10.1016/j.jaip.2016.09.024


BACKGROUND: Allergic diseases have seen a rise worldwide, with children suffering the highest burden. Thus, early prevention of allergic diseases is a public health priority. OBJECTIVE: To synthesize the evidence from randomized controlled trials (RCTs) assessing the effect of vitamin interventions during pregnancy on developing allergic diseases in offspring. METHODS: We searched CENTRAL, MEDLINE, SCOPUS, World Health Organization's International Clinical Trials Registration, E-theses, and Web of Science. Study quality was evaluated using Cochrane's risk of bias tool. Included RCTs had a minimum of 1-month follow-up postgestation. RESULTS: A total of 5 RCTs met the inclusion criteria, including 2456 children who used vitamins C + E (1 study), vitamin C (1 study), and vitamin D (3 studies) compared with placebo/control. Two studies were judged to have a high risk of bias for performance bias or a high rate of loss to follow-up. All were rated as low risk of bias for blinding of outcome assessment. We did not perform meta-analysis with vitamin C or vitamin C + E studies due to high heterogeneity between the 2 included studies. However, we did conduct a meta-analysis with trials on vitamin D (including 1493 children) and the results showed an association between the prenatal intake of vitamin D and the risk of developing recurrent wheeze in offspring (relative risk (RR), 0.812; 95% CI, 0.67-0.98). CONCLUSIONS: The current evidence suggests that prenatal supplementation of vitamin D might have a beneficial effect on recurrent wheezing in children. Longer-term follow-up of these studies is needed to ascertain whether this observed effect is sustained. There is lack of evidence on the effect of other vitamins for the prevention of respiratory and/or allergic outcomes.

Item Type:Article
Uncontrolled Keywords:allergic outcomes; asthma; clinical trial; eczema; effectiveness; efficacy; intervention; meta-analysis; offspring; respiratory outcomes; systematic review; vitamins; wheeze; wheezing; child; child of impaired parents; dietary supplements; drug hypersensitivity; female; humans; pregnancy; prenatal care; randomized controlled trials as topic; vitamins
Group:Faculty of Health & Social Sciences
ID Code:33622
Deposited By: Symplectic RT2
Deposited On:05 Mar 2020 16:15
Last Modified:14 Mar 2022 14:20


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