Skip to main content

Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment.

Tronchin, G., Akudjedu, T.N., Mohamed, A., Holleran, L., Hallahan, B., Cannon, D.M. and McDonald, C., 2020. Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment. Neuropsychopharmacology, 45, 1353-1361.

Full text available as:

[img] PDF
Progressive_subcortical_volume_Akudjedu.pdf - Accepted Version
Restricted to Repository staff only until 8 October 2020.
Available under License Creative Commons Attribution Non-commercial.

1MB

DOI: 10.1038/s41386-020-0665-4

Abstract

The association of antipsychotic medication with abnormal brain morphometry in schizophrenia remains uncertain. This study investigated subcortical morphometric changes 6 months after switching treatment to clozapine in patients with treatment-resistant schizophrenia compared with healthy volunteers, and the relationships between longitudinal volume changes and clinical variables. 1.5T MRI images were acquired at baseline before commencing clozapine and again after 6 months of treatment for 33 patients with treatment resistant schizophrenia and 31 controls, and processed using the longitudinal pipeline of Freesurfer v.5.3.0. Two-way repeated MANCOVA was used to assess group differences in subcortical volumes over time and partial correlations to determine association with clinical variables. Whereas no significant subcortical volume differences were found between patients and controls at baseline(F(8,52)=1.79; p= 0.101), there was a significant interaction between time, group and structure(F(7,143)=52.54, p<0.001). Corrected post-hoc analyses demonstrated that patients had significant enlargement of lateral ventricles (F(1,59)=48.89; p<0.001) and reduction of thalamus (F(1,59)=34.85; p<0.001), caudate (F(1,59)=59.35; p<0.001), putamen (F(1,59)=87.20; p<0.001) and hippocampus (F(1,59)=14.49; p<0.001) volumes. Thalamus and putamen volume reduction was associated with improvement in PANSS (r=0.42; p=0.021, r=0.39; p=0.033), SANS (r=0.36; p=0.049, r=0.40; p=0.027) and GAF (r=-0.39; p=0.038, r=-0.42; p=0.024) scores. Reduced thalamic volume over time was associated with increased serum clozapine level at follow-up (r=-0.44; p=0.010). Patients with treatment-resistant schizophrenia display progressive subcortical volume deficits after switching to clozapine despite experiencing symptomatic improvement. Thalamo-striatal progressive volumetric deficit associated with symptomatic improvement after clozapine exposure may reflect an adaptive response related to improved outcome rather than a harmful process.

Item Type:Article
ISSN:0893-133X
Group:Faculty of Health & Social Sciences
ID Code:34082
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:03 Jun 2020 11:22
Last Modified:08 Jul 2020 15:56

Downloads

Downloads per month over past year

More statistics for this item...
Repository Staff Only -