Marstaller, L., Burianová, H. and Reutens, D.C., 2016. Dynamic competition between large-scale functional networks differentiates fear conditioning and extinction in humans. Neuroimage, 134, 314 - 319.
Full text available as:
|
PDF
MarstallerEtAl_2016_Accepted.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 571kB | |
Copyright to original material in this document is with the original owner(s). Access to this content through BURO is granted on condition that you use it only for research, scholarly or other non-commercial purposes. If you wish to use it for any other purposes, you must contact BU via BURO@bournemouth.ac.uk. Any third party copyright material in this document remains the property of its respective owner(s). BU grants no licence for further use of that third party material. |
DOI: 10.1016/j.neuroimage.2016.04.008
Abstract
The high evolutionary value of learning when to respond to threats or when to inhibit previously learned associations after changing threat contingencies is reflected in dedicated networks in the animal and human brain. Recent evidence further suggests that adaptive learning may be dependent on the dynamic interaction of meta-stable functional brain networks. However, it is still unclear which functional brain networks compete with each other to facilitate associative learning and how changes in threat contingencies affect this competition. The aim of this study was to assess the dynamic competition between large-scale networks related to associative learning in the human brain by combining a repeated differential conditioning and extinction paradigm with independent component analysis of functional magnetic resonance imaging data. The results (i) identify three task-related networks involved in initial and sustained conditioning as well as extinction, and demonstrate that (ii) the two main networks that underlie sustained conditioning and extinction are anti-correlated with each other and (iii) the dynamic competition between these two networks is modulated in response to changes in associative contingencies. These findings provide novel evidence for the view that dynamic competition between large-scale functional networks differentiates fear conditioning from extinction learning in the healthy brain and suggest that dysfunctional network dynamics might contribute to learning-related neuropsychiatric disorders.
Item Type: | Article |
---|---|
ISSN: | 1053-8119 |
Uncontrolled Keywords: | associative learning; dynamic connectivity; neuroimaging; adaptation, physiological; adult; brain; conditioning, classical; extinction, psychological; fear; female; humans; male; nerve net; young adult |
Group: | Faculty of Science & Technology |
ID Code: | 34379 |
Deposited By: | Symplectic RT2 |
Deposited On: | 04 Aug 2020 13:31 |
Last Modified: | 14 Mar 2022 14:23 |
Downloads
Downloads per month over past year
Repository Staff Only - |