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The effects of moderate alterations in adrenergic activity on acute appetite regulation in obese women: A randomised crossover trial.

Tsofliou, F., Pitsiladis, Y.P., Lara, J., Hadjicharalambous, M., Macdonald, I.A., Wallace, M.A. and Lean, M.E.J., 2020. The effects of moderate alterations in adrenergic activity on acute appetite regulation in obese women: A randomised crossover trial. Nutrition and Health. (In Press)

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DOI: 10.1177/0260106020942117

Abstract

BACKGROUND: Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise. AIM: The present experiments investigated the effects of exogenous adrenaline and α/β adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensations and subsequent food intake in obese women. METHODS: A total of 10 obese women ((mean ± SEM), age: 50 (1.9) years, body mass index 36 (4.1) kg/m2, waist 104.8 (4.1) cm) participated in two separate, double-blind randomised experimental trials. Experiment 1: moderate exercise after α/β adrenergic blocker (labetalol, 100 mg orally) versus moderate exercise plus placebo; experiment 2: adrenaline infusion for 20 minutes versus saline infusion. Appetite/satiety and biochemistry were measured at baseline, pre- and immediately post-intervention, then 1 hour post-intervention (i.e., before dinner). Food intake was assessed via ad libitum buffet-style dinner. RESULTS: No differences were found in appetite/satiety, subsequent food intake or serum leptin in any of the studies (experiment 1 or experiment 2). In experiment 1, blood glucose was higher (p < 0.01) and plasma free fatty acids lower (p = 0.04) versus placebo. In experiment 2, plasma free fatty acids (p < 0.05) increased after adrenaline versus saline infusion. CONCLUSIONS: Neither inhibition of exercise-induced adrenergic activity by combined α/β adrenergic blockade nor moderate increases in adrenergic activity induced by intravenous adrenaline infusion affected acute appetite regulation.

Item Type:Article
ISSN:0260-1060
Uncontrolled Keywords:Appetite regulation ; adrenaline infusion ; adrenergic blockade ; moderate exercise ; obesity
Group:Faculty of Health & Social Sciences
ID Code:34393
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:05 Aug 2020 13:05
Last Modified:10 Aug 2020 11:56

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