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Functional Interplay Between Posterior Parietal Cortex and Hippocampus During Detection of Memory Targets and Non-targets.

Ciaramelli, E., Burianová, H., Vallesi, A., Cabeza, R. and Moscovitch, M., 2020. Functional Interplay Between Posterior Parietal Cortex and Hippocampus During Detection of Memory Targets and Non-targets. Frontiers in Neuroscience, 14, 563768.

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DOI: 10.3389/fnins.2020.563768

Abstract

© Copyright © 2020 Ciaramelli, Burianová, Vallesi, Cabeza and Moscovitch. Posterior parietal cortex is frequently activated during episodic memory retrieval but its role during retrieval and its interactions with the hippocampus are not yet clear. In this fMRI study, we investigated the neural bases of recognition memory when study repetitions and retrieval goals were manipulated. During encoding participants studied words either once or three times, and during retrieval they were rewarded more to detect either studied words or new words. We found that (1) dorsal parietal cortex (DPC) was more engaged during detection of items studied once compared to three times, whereas regions in the ventral parietal cortex (VPC) responded more to items studied multiple times; (2) DPC, within a network of brain regions functionally connected to the anterior hippocampus, responded more to items consistent with retrieval goals (associated with high reward); (3) VPC, within a network of brain regions functionally connected to the posterior hippocampus, responded more to items not aligned with retrieval goals (i.e., unexpected). These findings support the hypothesis that DPC and VPC regions contribute differentially to top-down vs. bottom-up attention to memory. Moreover, they reveal a dissociation in the functional profile of the anterior and posterior hippocampi.

Item Type:Article
ISSN:1662-4548
Uncontrolled Keywords:episodic memory, recognition memory decision, posterior parietal cortex, hippocampus, functional magnetic brain imaging (fMRI)
Group:Faculty of Science & Technology
ID Code:34917
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:01 Dec 2020 09:40
Last Modified:15 Aug 2021 08:27

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