Skip to main content

18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology.

Kalimuddin, S., Xie, W., Watanabe, S., Tham, J.Y., Sam, H., Chan, K.W.K., Yap, T.S., Totman, J. J., Chacko, A-M., Vasudevan, S.G. and Low, J.G., 2021. 18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology. Antiviral Research, 185 (January), 104991.

Full text available as:

[img]
Preview
PDF (OPEN ACCESS ARTICLE)
1-s2.0-S0166354220304058-main.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

1MB

DOI: 10.1016/j.antiviral.2020.104991

Abstract

In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.

Item Type:Article
ISSN:0166-3542
Uncontrolled Keywords:Dengue ; FDG-PET ; Inflammation ; Pathogenesis
Group:Faculty of Health & Social Sciences
ID Code:35131
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:01 Feb 2021 16:30
Last Modified:01 Feb 2021 16:30

Downloads

Downloads per month over past year

More statistics for this item...
Repository Staff Only -