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Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study.

Cabrera, D., Kruger, M., Wolber, F.M., Roy, N.C., Totman, J. J., Henry, C.J., Cameron-Smith, D. and Fraser, K., 2018. Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study. International Journal of Environmental Research and Public Health, 15 (5), 1045.

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DOI: 10.3390/ijerph15051045

Abstract

The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model. Plasma concentrations of eight glycerophospholipid, glycerolipid, and sphingolipid species were significantly lower in menopausal women with low BMD but higher in two glycerophospholipid species (phosphatidylinositol and phosphatidic acid). Further, this study found no significant differences in plasma amino acid metabolites. However, trends for lower 4-aminobutyric acid, turanose, proline, aminopropionitrile, threonine, and methionine were found in women with low BMD. This pilot study identified associations between lipid metabolism and femoral neck BMD in SC women. Further studies are required on larger populations for evaluating the bone health effect of these compounds and their usefulness as clinical biomarkers for osteoporosis prediction in women.

Item Type:Article
ISSN:1660-4601
Uncontrolled Keywords:biomarkers ; lipidomics ; menopause ; metabolomics ; osteoporosis ; Aged ; Amino Acids ; Asian Continental Ancestry Group ; Biomarkers ; Bone Density ; Case-Control Studies ; China ; Female ; Humans ; Lipids ; Metabolomics ; Middle Aged ; Osteoporosis, Postmenopausal ; Pilot Projects ; Singapore
Group:Faculty of Health & Social Sciences
ID Code:35133
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:01 Feb 2021 16:51
Last Modified:15 Aug 2021 08:27

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