Skip to main content

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years.

Dima, D., Modabbernia, A., Papachristou4, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T.. N., Albajes-Eizagirre, A., Alnaes, D, Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D. I., Borgwardt, S., Bourque, J., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R. M., Buitelaar, J. K., Busatto, G. F., Buckner, R. L., Calhoun, V., Canales-Rodríguez, E. J., Cannon, D. M., Caseras, X., Castellanos, F. X., Cervenka, S, Chaim-Avancini, T. M., Ching, C. R. K., Chubar, V., Clark, V. P., Conrod, P., Conzelmann, A., Crespo-Facorro, B, Crivello, F., Crone, E. A., Dale, A. M., Davey, C., de Geus, E. J. C, de Haan, L., de Zubicaray, G. I., den Braber, A., Dickie, E. W., Di Giorgio, A., Doan, N. T., Dørum, E. S., Ehrlich, S., Erk, S., Espeseth, T., Fatouros- Bergman, H., Fisher, S. E., Fouche, J. P., Franke, B., Frodl, T., Fuentes-Claramonte, P., Glahn, D. C., Gotlib, I. H., Grabe, H. J., Grimm, O., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Gur, R. E., Gur, R. C., Harrison, B. J., Hartman, C. A., Hatton, S. N., Heinz, A., Heslenfeld, D. J., Hibar, D. P., Hickie, I. B., Ho, B. C., Hoekstra, P. J., Hohmann, S., Holmes, A. J., Hoogman, M., Hosten, N., Howells, F. M., Hulshoff Pol, H. E., Huyser, C., Jahanshad, N., James, A., Jernigan, T. L., Jiang, J., Jönsson, E. G., Joska, J. A., Kahn, R., Kalnin, A., Kanai, R., Klein, M., Klyushnik, T. P., Koenders, L., Koops, S., Krämer, B., Kuntsi, J., Lagopoulos, J., Lázaro, L., Lebedeva, I., Lee, W. H., Lesch, K. P., Lochner, C., Machielsen, M. W. J., Maingault, S., Martin, N. G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, C., McDonald, B. C., McIntosh, A. M., McMahon, K. L., McPhilemy, G., Menchón, J. M., Medland, S. E., Meyer-Lindenberg, A., Naaijen, J., Najt, P., Nakao, T., Nordvik, J. E., Nyberg, L., Oosterlaan, J., Ortiz-García de la Foz, V., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M. J., Potkin, S. G., Radua, J., Reif, A., Rinker, D. A., Roffman, J. L., Rosa, P. G. P., Sacchet, M. D., Sachdev, P. S., Salvador, R., Sánchez-Juan, P., Sarró, S., Satterthwaite, T. D., Saykin, A. J., Serpa, M. H., Schmaal, L., Schnell, K., Schumann, G., Sim, K., Smoller, J. W., Sommer, I., Soriano-Mas, C., Stein, D. J., Strike, L. T., Swagerman, S. C., Tamnes, C. K., Temmingh, H. S., Thomopoulos, S. I., Tomyshev, A. S., Tordesillas-Gutiérrez, D., Trollor, J. N., Turner, J. A., Uhimann, A., van den Heuvel, O. A., van den Meer, D., van der Wee, N. J. A., van Haren, N. E. M., van't Ent, D., van Erp, T. G. M., Veer, I. M., Veltman, D. J., Voineskos, A., Völzke, H., Walter, H., Walton, E., Wang, L., Wang, Y., Wassink, T. H., Weber, B., Wen, W., West, J. D., Westlye, L. T., Whalley, H., Wierenga, L. M., Williams, S. C. R., Wittfeld, K., Wolf, D. H., Worker, A., Wright, M. J., Yang, K., Yoncheva, Y., Zanetti, M. V., Ziegler, G. C., Thompson, P. M., Frangou, S. and Karolinska Schizophrenia Project (KaSP), , 2021. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. (In Press)

Full text available as:

[img]
Preview
PDF (OPEN ACCESS ARTICLE)
hbm.25320.pdf - Published Version
Available under License Creative Commons Attribution.

2MB

DOI: 10.1002/hbm.25320

Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to examine age‐related trajectories inferred from cross‐sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter‐individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age‐related morphometric patterns.

Item Type:Article
ISSN:1065-9471
Additional Information:Research Funding National Institute of Mental Health. Grant Numbers: MH104284, MH116147, R01MH113619, R01 MH090553, R01MH117014, R01MH042191 Karolinska Institutet Stockholm County Council Southern and Eastern Norway Regional Health Authority German Centre for Cardiovascular Research DZHK Siemens Healthineers University of Queensland US National Institute of Child Health and Human Development. Grant Number: RO1HD050735 Australian National Health and Medical Research Council Eunice Kennedy Shriver National Institute of Child Health & Human Development National Institute on Drug Abuse. Grant Numbers: UL1 TR000153, 1 U24 RR025736‐01, 1 U24 RR021992 Brain Injury Fund Research Grant Program Indiana State Department of Health Spinal Cord Parents Against Childhood Epilepsy Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures Epilepsy Foundation American Epilepsy Society Knut and Alice Wallenberg Foundation European Community's Horizon 2020 Programme Vici Innovation Program NWO Brain & Cognition Excellence Program Netherlands Organization for Scientific Research Hersenstichting Nederland Netherlands Organization for Health Research and Development Geestkracht Programme of the Dutch Health Research Council. Grant Number: 10‐000‐1001 Universiteit Utrecht FP7 Ideas: European Research Council Nederlandse Organisatie voor Wetenschappelijk Onderzoek National Center for Advancing Translational Sciences National Institutes of Health National Center for Research Resources Consortium grant. Grant Number: U54 EB020403 U.S. National Institutes of Health. Grant Numbers: R01 CA101318, P30 AG10133, R01 AG19771 Medical Research Council. Grant Number: G0500092 Fundación Instituto de Investigación Marqués de Valdecilla. Grant Numbers: API07/011, NCT02534363, NCT0235832 Instituto de Salud Carlos III. Grant Numbers: PI14/00918, PI14/00639, PI060507, PI050427, PI020499 the Research Council. Grant Number: 223273 South Eastern Norway Regional Health Authority. Grant Numbers: 2017‐112, 2019107 Swedish Research Council European Community's Seventh Framework Programme. Grant Number: 602450 King's College London South London and Maudsley NHS Foundation Trust Biomedical Research Centre National Institute for Health Research
Uncontrolled Keywords:brain morphometry; ENIGMA; longitudinal trajectories; multisite
Group:Faculty of Health & Social Sciences
ID Code:35186
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:11 Feb 2021 17:30
Last Modified:27 May 2021 07:55

Downloads

Downloads per month over past year

More statistics for this item...
Repository Staff Only -