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White Matter Microstructure and Structural Networks in Treatment-Resistant Schizophrenia Patients After Commencing Clozapine Treatment: A Longitudinal Diffusion Imaging Study.

Tronchin, G., McPhilemy, G., Ahmed, M., Kilmartin, L., Costello, L., Forde, N.J., Nabulsi, L., Akudjedu, T.N., Holleran, L., Hallahan, B., Cannon, D.M. and McDonald, C., 2021. White Matter Microstructure and Structural Networks in Treatment-Resistant Schizophrenia Patients After Commencing Clozapine Treatment: A Longitudinal Diffusion Imaging Study. Psychiatry Research, 298 (April), 113772.

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DOI: 10.1016/j.psychres.2021.113772

Abstract

This study investigates changes on white matter microstructure and neural networks after 6 months of switching to clozapine in schizophrenia patients compared to controls, and whether any changes are related to clinical variables. T1 and diffusion-weighted MRI images were acquired at baseline before commencing clozapine and after 6 months of treatment for 22 patients with treatment-resistant schizophrenia and 23 controls. The Tract-based spatial statistics approach was used to compare changes over time between groups in fractional anisotropy (FA). Changes in structural network organisation weighted by FA and number of streamlines were assessed using graph theory. Patients displayed a significant reduction of FA over time (p<0.05) compared to controls in the genu and body of the corpus callosum and bilaterally in the anterior and superior corona radiata. There was no correlation between FA change in patients and changes in clinical variables or serum level of clozapine. There was no changes in structural network organisation between groups (F(7,280)=2.80;p = 0.187). This longitudinal study demonstrated progressive focal FA abnormalities in key anterior tracts, but preserved brain structural network organisation in patients. The FA reduction was independent of any clinical measures and may reflect progression of the underlying pathophysiology of this malignant form of schizophrenia illness.

Item Type:Article
ISSN:0165-1781
Uncontrolled Keywords:Refractory schizophrenia; Longitudinal; Diffusion MRI; Clozapine; Fractional anisotropy; TBSS; Structural connectivity
Group:Faculty of Health & Social Sciences
ID Code:35226
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:24 Feb 2021 12:25
Last Modified:24 Feb 2021 12:25

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