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The relation of structural integrity and task-related functional connectivity in the aging brain.

Burianová, H., Marstaller, L., Choupan, J., Sepehrband, F., Ziaei, M. and Reutens, D., 2015. The relation of structural integrity and task-related functional connectivity in the aging brain. Neurobiology of Aging, 36 (10), 2830 -2837.

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DOI: 10.1016/j.neurobiolaging.2015.07.006

Abstract

The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

Item Type:Article
ISSN:0197-4580
Uncontrolled Keywords:Age-related compensation; Functional connectivity; Gray matter; Structural integrity; White matter; Adult; Aged; Aging; Brain; Cognition; Diffusion Magnetic Resonance Imaging; Female; Humans; Male; Memory; Middle Aged; Nerve Net; Neuroimaging; Organ Size; Young Adult
Group:Faculty of Science & Technology
ID Code:35327
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:25 Mar 2021 16:12
Last Modified:27 May 2021 07:54

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