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Intermittent Use of Portable NIV Increases Exercise Tolerance in COPD: A Randomised, Cross-Over Trial.

Vogiatzis, I., Chynkiamis, N., Armstrong, M., Lane, N.D., Hartley, T., Gray, W.K. and Bourke, S.C., 2019. Intermittent Use of Portable NIV Increases Exercise Tolerance in COPD: A Randomised, Cross-Over Trial. Journal of Clinical Medicine, 8 (1), 1-16.

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Official URL: https://www.mdpi.com/2077-0383/8/1/94

DOI: 10.3390/jcm8010094

Abstract

During exercise, non-invasive ventilation (NIV) prolongs endurance in chronic obstructive pulmonary disease (COPD), but routine use is impractical. The VitaBreath device provides portable NIV (pNIV); however, it can only be used during recovery. We assessed the effect of pNIV compared to pursed lip breathing (PLB) on exercise tolerance. Twenty-four COPD patients were randomised to a high-intensity (HI: 2-min at 80% peak work rate (WRpeak) alternated with 2-min recovery; n = 13), or a moderate-intensity (MOD: 6-min at 60% WRpeak alternated with 2-min recovery; n = 11) protocol, and within these groups two tests were performed using pNIV and PLB during recovery in balanced order. Upon completion, patients were provided with pNIV; use over 12 weeks was assessed. Compared to PLB, pNIV increased exercise tolerance (HI: by 5.2 ± 6.0 min; MOD: by 5.8 ± 6.7 min) (p < 0.05). With pNIV, mean inspiratory capacity increased and breathlessness decreased by clinically meaningful margins during recovery compared to the end of exercise (HI: by 140 ± 110 mL and 1.2 ± 1.7; MOD: by 170 ± 80 mL and 1.0 ± 0.7). At 12 weeks, patients reported that pNIV reduced anxiety (median: 7.5/10 versus 4/10, p = 0.001) and recovery time from breathlessness (17/24 patients; p = 0.002); 23/24 used the device at least weekly. pNIV increased exercise tolerance by reducing dynamic hyperinflation and breathlessness in COPD patients.

Item Type:Article
ISSN:2077-0383
Additional Information:This article belongs to the Special Issue Pulmonary Rehabilitation, Exercise Training and Physical Activity Coaching for Chronic Lung Disorders
Uncontrolled Keywords:COPD ; exercise tolerance ; non-invasive ventilation ; pulmonary rehabilitation
Group:Faculty of Health & Social Sciences
ID Code:35925
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:25 Aug 2021 10:23
Last Modified:25 Aug 2021 10:23

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