Skip to main content

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes.

Cotton, S, McHugh, M., Dewar, R, Haas, J., Templeton, K, Robson, S., Connor, T., Loman, N., Golubchik, T, Martinez Nunez, R., Bonsall, D, Rambaut, A, Snell, L., Livett, R, Ludden, C, Corden, S, Nastouli, E, Nebbia, G, Johnston, I, Prieto, J., Saeed, K, Jackson, D., Houlihan, C, Frampton, D, Hamilton, W., Witney, A., Bucca, G, Pope, C., Moore, C, Thomson, E., Cutino-Moguel, T, Harrison, E., Smith, C., Rogan, F, Beckwith, S., Murray, A, Singleton, D, Eastick, K, Sheridan, L., Randell, P, Jackson, L., Ariani, C., Gonçalves, S, Fairley, D., Loose, M., Watkins, J, Moses, S, Nicholls, S, Bull, M, Amato, R, Smith, D., Aanensen, D., Barrett, J., Kele, B, Aggarwal, D, Shepherd, J., Curran, M., Parmar, S, Parker, M., Williams, C, Glaysher, S, Underwood, A., Bashton, M, Pacchiarini, N, Loveson, K., Byott, M, Carabelli, A., Templeton, K., Peacock, S., de Silva, T., Wang, D, Langford, C., Sillitoe, J, Gunson, R., Cottrell, S, O’Grady, J, Kwiatkowski, D, Lillie, P., Cortes, N, Moore, N, Thomas, C, Burns, P., Mahungu, T., Liggett, S, Beckett, A., Holden, M., Levett, L., Osman, H, Hassan-Ibrahim, M., Simpson, D., Chand, M, Gupta, R., Darby, A., Paterson, S, Pybus, O., Volz, E., de Angelis, D, Robertson, D., Page, A., Martincorena, I, Aigrain, L, Bassett, A., Wong, N, Taha, Y, Erkiert, M., Spencer Chapman, M., Dewar, R, McHugh, M., Mookerjee, S, Aplin, S, Harvey, M, Sass, T, Umpleby, H, Wheeler, H, McKenna, J., Warne, B, Taylor, J., Chaudhry, Y, Izuagbe, R, Jahun, A., Young, G., McMurray, C, McCann, C., Nelson, A, Elliott, S, Lowe, H, Price, A, Crown, M., Rey, S, Roy, S, Temperton, B, Shaaban, S, Hesketh, A., Laing, K., Monahan, I., Heaney, J, Pelosi, E, Silviera, S, Wilson-Davies, E, Fryer, H, Adams, H, du Plessis, L, Johnson, R, Harvey, W., Hughes, J, Orton, R., Spurgin, L., Bourgeois, Y, Ruis, C, O'Toole, Á, Gourtovaia, M, Sanderson, T, Fraser, C, Edgeworth, J, Breuer, J, Michell, S., Todd, J., John, M, Buck, D, Gajee, K, Kay, G., Heyburn, D, Charalampous, T, Alcolea-Medina, A, Kitchman, K, McNal, A, Pritch, D., Dervisevic, S, Muir, P, Robinson, E, Vipond, B., Ramadan, N., Jeanes, C, Weldon, D, Catalan, J, Jones, N, da Silva Filipe, A, Williams, C, Fuchs, M, Miskelly, J, Jeffries, A., Oliver, K, Park, N., Ash, A, Koshy, C, Barrow, M, Buchan, S., Mantzouratou, A., Clark, G, Holmes, C., Campbell, S, Davis, T, Tan, N., Brown, J., Harris, K., Kidd, S., Grant, P., Xu-McCrae, L, Cox, A, Madona, P, Pond, M, Randell, P., Withell, K., Williams, C, Graham, C, Denton-Smith, R, Swindells, E, Turnbull, R, Sloan, T., Bosworth, A, Hutchings, S, Pymont, H., Casey, A, Ratcliffe, L, Jones, C., Knight, B., Haque, T, Hart, J, Irish-Tavares, D, Witele, E, Mower, C, Watson DipHe, L., Collins, J, Eltringham, G, Crudgington, D, Macklin, B, Iturriza-Gomara, M, Lucaci, A., McClure, P., Carlile, M, Holmes, N, Moore, C, Storey, N, Rooke, S, Yebra, G, Craine, N, Perry, M, Alikhan, N, Bridgett, S, Cook, K., Fearn, C, Goudarzi, S, Lyons, R., Williams, T, Haldenby, S., Durham, J, Leonard, S, Davies, R., Batra, R, Blane, B, Spyer, M., Smith, P, Yavus, M, Williams, R., Mahanama, A., Samaraweera, B, Girgis, S., Hansford, S., Green, A, Beaver, C, Bellis, K., Dorman, M., Kay, S, Prestwood, L, Rajatileka, S, Quick, J, Poplawski, R, Reynolds, N, Mack, A, Morriss, A, Whalley, T, Patel, B, Georgana, I, Hosmillo, M, Pinckert, M., Stockton, J, Henderson, J., Hollis, A, Stanley, W, Yew, W., Myers, R, Thornton, A, Adams, A, Annett, T, Asad, H, Birchley, A, Coombes, J, Evans, J., Fina, L, Gatica-Wilcox, B, Gilbert, L, Graham, L, Hey, J, Hilvers, E, Jones, S, Jones, H, Kumziene-Summerhayes, S, McKerr, C, Powell, J, Pugh, G, Taylor, S, Trotter, A., Williams, C., Kermack, L., Foulkes, B., Gallis, M, Hornsby, H., Louka, S., Pohare, M, Wolverson, P, Zhang, P, MacIntyre-Cockett, G, Trebes, A, Moll, R., Ferguson, L, Goldstein, E., Maclean, A, Tomb, R, Starinskij, I, Thomson, L, Southgate, J, Kraemer, M., Raghwani, J, Zarebski, A., Boyd, O, Geidelberg, L, Illingworth, C., Jackson, C, Pascall, D, Vattipally, S, Freeman, T., Hsu, S., Lindsey, B., James, K, Lewis, K, Tonkin-Hill, G, Tovar-Corona, J., Cox, M, Abudahab, K, Menegazzo, M, Taylor, B., Yeats, C., Mukaddas, A, Wright, D., de Oliveira Martins, L, Colquhoun, R, Hill, V, Jackson, B, McCrone, J., Medd, N, Scher, E, Keatley, J, Curran, T, Morgan, S, Maxwell, P, Smith, K, Eldirdiri, S, Kenyon, A, Holmes, A., Price, J., Wyatt, T, Mather, A., Skvortsov, T, Hartley, J., Guest, M, Kitchen, C, Merrick, I, Munn, R, Bertolusso, B, Lynch, J, Vernet, G, Kirk, S, Wastnedge, E, Stanley, R, Idle, G, Bradley, D., Killough, N., Poyner, J, Mori, M, Jones, O, Wright, V, Brooks, E, Churcher, C., Delgado Callico, L, Fragakis, M, Galai, K, Jermy, A, Judges, S, Markov, A, McManus, G., Smith, K., Thomas-McEwen, P., Westwick, E, Attwood, S., Bolt, F, Davies, A, De Lacy, E, Downing, F, Edwards, S, Meadows, L, Jeremiah, S, Smith, N, Foulser, L, Patel, A, Berry, L, Boswell, T, Fleming, V., Howson-Wells, H., Joseph, A, Khakh, M, Lister, M., Bird, P., Fallon, K, Helmer, T, McMurray, C., Odedra, M, Shaw, J, Tang, J., Willford, N., Blakey, V, Raviprakash, V, Sheriff, N, Williams, L, Feltwell, T, Bedford, L, Cargill, J., Hughes, W, Moore, J, Stonehouse, S, Atkinson, L, Lee, J., Shah, D, Ohemeng-Kumi, N, Ramble, J, Sehmi, J, Williams, R, Chatterton, W, Pusok, M, Everson, W, Castigador, A, Macnaughton, E, El Bouzidi, K, Lampejo, T, Sudhanva, M, Breen, C, Sluga, G, Ahmad, S., George, R., Machin, N., Binns, D, James, V, Blacow, R, Coupland, L, Smith, L, Barton, E, Padgett, D, Scott, G, Cross, A, Mirfenderesky, M, Greenaway, J, Cole, K, Clarke, P, Duckworth, N, Walsh, S, Bicknell, K, Impey, R, Wyllie, S, Hopes, R, Bishop, C, Chalker, V, Harrison, I, Gifford, L, Molnar, Z, Auckland, C, Evans, C, Johnson, K, Partridge, D., Raza, M, Baker, P, Bonner, S, Essex, S, Murray, L., Lawton, A., Burton-Fanning, S, Payne, B., Waugh, S, Gomes, A., Kimuli, M, Murray, D., Ashfield, P, Dobie, D, Ashford, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Driscoll, M, Ensell, L, Lowe, H., Maftei, L, Mondani, M, Chaloner, N., Cogger, B., Easton, L., Huckson, H, Lewis, J, Lowdon, S, Malone, C., Munemo, F, Mutingwende, M, Nicodemi, R, Podplomyk Fd, O, Somassa, T, Beggs, A, Richter, A, Cormie, C, Dias, J, Forrest, S, Higginson, E., Maes, M, Young, J, Davidson, R., Jackson, K., Keeley, A., Ball, J, Byaruhanga, T, Chappell, J., Dey, J, Hill, J., Park, E., Fanaie, A, Hilson, R., Yaze, G, Lo, S, Afifi, S, Beer, R, Maksimovic, J, McCluggage, K, Spellman, K, Bresner, C, Fuller, W, Marchbank, A, Workma, T, Shelest, E, Debebe, J, Sang, F, Francois, S, Gutierrez, B, Vasylyeva, T., Flaviani, F, Ragonnet-Cronin, M, Smollett, K., Broos, A, Mair, D, Nichols, J, Nomikou, K, Tong, L, Tsatsani, I, O'Brien, S, Rushton, S, Sanderson, R, Perkins, J, Cotton, S, Gallagher, A, Allara, E, Pearson, C, Bibby, D, Dabrer, G, Ellaby, N, Gallagher, E, Hubb, J, Lackenby, A, Lee, D, Manesis, N, Mbisa, T, Platt, S, Twohig, K., Morgan, M, Aydin, A, Baker, D., Foster-Nyarko, E, Prosolek, S., Rudder, S, Baxter, C, Carvalho, S., Lavin, D, Mariappan, A, Radulescu, C, Singh, A, Tang, M, Morcrette, H, Bayzid, N, Cotic, M, Balcazar, C., Gallagher, M., Maloney, D, Stanton, T., Williamson, K., Manley, R, Michelsen, M., Sambles, C., Studholme, D., Warwick-Dugdale, J, Eccles, R, Gemmell, M, Gregory, R, Hughes, M, Nelson, C, Rainbow, L, Vamos, E., Webster, H., Whitehead, M, Wierzbicki, C, Angyal, A, Green, L., Whiteley, M, Betteridge, E, Bronner, I., Farr, B., Goodwin, S, Lensing, S., McCarthy, S., Quail, M., Rajan, D, Redshaw, N., Scott, C, Shirley, L, Thurston, S., Rowe, W, Gaskin, A, Le-Viet, T, Bonfield, J, Liddle, J and Whitwham, A, 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection, 135, 28-36.

Full text available as:

[img]
Preview
PDF (OPEN ACCESS ARTICLE)
1-s2.0-S0195670123000671-main.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

455kB

DOI: 10.1016/j.jhin.2023.02.010

Abstract

Summary Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine.

Item Type:Article
ISSN:0195-6701
Uncontrolled Keywords:SARS-CoV-2; Introduction; Hospital discharge; Care homes
Group:Faculty of Science & Technology
ID Code:38624
Deposited By: Symplectic RT2
Deposited On:26 May 2023 13:50
Last Modified:26 May 2023 13:50

Downloads

Downloads per month over past year

More statistics for this item...
Repository Staff Only -