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Progression of neuroanatomical abnormalities after first-episode of psychosis: A 3-year longitudinal sMRI study.

Akudjedu, T.N., Giulia, T., McInerney, S., Scanlon, C., Kenney, J.P.M., McFarland, J., Barker, G.J., McCarthy, P., Cannon, D.M., McDonald, C. and Hallahan, B., 2020. Progression of neuroanatomical abnormalities after first-episode of psychosis: A 3-year longitudinal sMRI study. Journal of Psychiatric Research, 130 (Nov), 137-151.

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Abstract

The location, extent and progression of longitudinal morphometric changes after first-episode of psychosis (FEP) remains unclear. We investigated ventricular and cortico-subcortical regions over a 3-year period in FEP patients compared with healthy controls. High resolution 1.5T T1-weighted MR images were obtained at baseline from 28 FEP patients at presentation and 28 controls, and again after 3-years. The longitudinal FreeSurfer pipeline (v.5.3.0) was used for regional volumetric and cortical reconstruction image analyses. Repeated-measures ANCOVA and vertex-wise linear regression analyses compared progressive changes between groups in subcortical structures and cortical thickness respectively. Compared with controls, patients displayed progressively reduced volume of the caudate [F (1,51)=5.86, p=0.02, Hedges’ g=0.66], putamen [F (1,51)=6.06, p=0.02, g=0.67], thalamus [F (1,51)=6.99, p=0.01, g=0.72] and increased right lateral ventricular volume [F (1, 51)=4.03, p=0.05], and significantly increased rate of cortical thinning [F (1,52)=5.11, p=0.028)] at a mean difference of 0.84% [95% CI (0.10, 1.59)] in the left lateral orbitofrontal region over the 3-year period. In patients, greater reduction in putamen volume over time was associated with lower cumulative antipsychotic medication dose (r=0.49, p=0.01), and increasing lateral ventricular volume over time was associated with worsening negative symptoms (r=0.41, p=0.04) and poorer global functioning (r= −0.41, p=0.04). This study demonstrates localised progressive structural abnormalities in the cortico-striato-thalamo-cortical circuit after the onset of psychosis, with increasing ventricular volume noted as a neuroanatomical marker of poorer clinical and functional outcome.

Item Type:Article
ISSN:0022-3956
Uncontrolled Keywords:First-episode psychosis; Schizophrenia; Structural MRI; Subcortical structures; Cortical thickness; Longitudinal study
Group:Faculty of Health & Social Sciences
ID Code:34457
Deposited By: Unnamed user with email symplectic@symplectic
Deposited On:27 Aug 2020 09:24
Last Modified:27 Aug 2020 09:24

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